Increasing Competitiveness through innovation in biotechnology

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Enablers:

• Unification of regulatory approval
• Continuously growing demand for new medical applications
• Aging population
• THE POTENTIAL OF NANOTECHNOLOGY

Inhibitors:

• Insufficient connectivity between the key players Decline of (R&D) cooperation between public and private
• Unnecessary regulatory, administrative or economic obstacles.
• Ethical concerns on genetic research
• IP rights regulations struggles to catch changes in the new business environment

Paradigms:

The traditional chemical paradigm of drug discovery and development is being replaced by a new biotechnological methods

Experts:

Prof. S. Raghunath (Email)
Thomas Joseph (Email)

Timing:

Notable events in the history of biotechnology:
* before 8000 BC – Collecting of seeds for replanting. Evidence that Mesopotamian people used selective breeding (artificial selection) practices to improve livestock.
* around 7000 BC – Brewing beer, fermenting wine, baking bread with help of yeast.
* 8000 BC - 3000 BC – Yogurt and cheese made with lactic-acid-producing bacteria by various cultures.
* 1590 – The microscope is invented by Zacharias Janssen.
* 1675 – Microorganisms discovered by Anton van Leeuwenhoek.
* 1856 – Gregor Mendel discovered the laws of inheritance.
* 1862 – Louis Pasteur discovered the bacterial origin of fermentation.
* 1919 – Karl Ereky, a Hungarian agricultural engineer, first used the word biotechnology.
* 1928 – Alexander Fleming noticed that a certain mould could stop the duplication of bacteria, leading to the first antibiotic: penicillin.
* 1953 – James D. Watson and Francis Crick describe the structure of deoxyribonucleic acid, called DNA for short.
* 1972 – The DNA composition of chimpanzees and gorillas is discovered to be 99% similar to that of humans.
* 1975 – Method for producing monoclonal antibody developed by Kohler and Milstein.
* 1980 – Modern biotech is characterized by recombinant DNA technology. The prokaryote model, E. coli, is used to produce synthetic insulin and other medicine, in human form. (It is estimated that only 5% of diabetics were allergic to animal insulins available before, while new evidence suggests that type 1 diabetes mellitus is caused by an allergy to human insulin). A viable brewing yeast strain, Saccharomyces cerevisiae 1026, acts as a modifier of the microflora in the rumen of cows and digestive tract of horses). The United States Supreme Court, in 447 U.S. 303 (1980), rules in favor of microbiologist Ananda Chakrabarty in the case of a USPTO request for a first patent granted to a genetically modified living organism (GMO) in history.
* 1984 – Nutrigenomics as applied science in animal nutrition.
* 1994 – the U.S. Food and Drug Administration approves of the first GM food: the "Flavr Savr" tomato.
* 1997 – British scientists, led by Ian Wilmut, from the Roslin Institute report cloning a sheep called Dolly the sheep using DNA from two adult sheep
* cells.
* 2000 – Completion of a, "rough draft," of the human genome in the Human Genome Project.
* 2002 – Researchers sequence the DNA of rice, the main food source for two-thirds of the world's population. Rice is the first crop to have its genome decoded.
* 2003 – GloFish, the first biotech pet, hits the North American market. Specially bred to detect water pollutants, the fish glows red under black light thanks to the addition of a natural bioluminescence gene.
* 2004 –
- November – Korean researchers treat spinal cord injury by transplanting multipotent adult stem cells from an umbilical cord blood.
- December – A team of researchers at the University of Paris develops a method to produce large number of red blood cells from hematopoietic stem cells, creating an environment that mimics the conditions of bone marrow.
* 2005 –
- January – Researchers at the University of Wisconsin-Madison differentiate human blastocyst stem cells into neural stem cells, and finally into spinal motor neuron cells.

* See also "Historical Events in Biotechnology" from The Biotechnology Institute http://www.biotechinstitute.org/what_is/timeline.html

Web Resources:

• Innovation in Pharmaceutical Biotechnology: Comparing National Innovation Systems at the Sectoral Level, OECD, 2006 (http://www.oecd.org/document/55/0,3343,en_2649_34273_36446711_1_1_1_1,00.html)

• Sustaining Competitiveness through Alliances and Innovation: The impact of Alliance Management Issues on learning skills and competencies from partner(s), Prof. S. Raghunath (Email), Thomas Joseph (Email), (http://dspace.iimk.ac.in/bitstream/2259/492/1/349-358+.pdf)

• European Commission - Enterprise and Industry Directorate General - Consumer goods - (http://ec.europa.eu/enterprise/phabiocom/index_en.htm)