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Covalent variants can be prepared by linking functionalities to groups which are found in the amino acid chain or at the N- or C-terminal residue, as is known in the art. For example, amino acid sequence variants of a reference polypeptide can be prepared by mutations in the DNA. Preferably, amino acid changes in the protein variants disclosed herein are conservative amino acid changes, i.e., substitutions of similarly charged or uncharged amino acids. The TM domain may be derived from (i.e., comprise at least the transmembrane region(s) of) the alpha, beta or zeta chain of the T-cell receptor, CD3.epsilon., CD3.zeta., CD4, CD5, CD8.alpha., CD9, CD 16, CD22, CD27, CD28, CD33, CD37, CD45, CD64, CD80, CD86, CD 134, CD137, CD152, CD 154, and PD1. With the help of her Best Cam Site friend, lawyer George Denham (Jack Lemmon) she battles Malone in anyway she can but despite her troubles things may turn out alright in more sense than one